Endocrine Abstracts

A previously well 49 year old woman was referred to our endocrine service with a compelling 4 month history of polyuria and polydipsia. Her 24 h fluid intake was estimated to be 12 l with 4 l of this taken overnight; these estimates had doubled in the 2 months since referral. Due to the development of an increasingly severe frontal headache, her GP organised a CT head scan which was largely unremarkable aside from a ‘slight fullness’ to the pituitary gland. Pituitary...

A 42 year old man was referred to the acute medical unit with accelerated hypertension in March 2015. He presented with headache and blurred vision due to hypertensive retinopathy. Pre-treatment BP was 186/131 mmHg. Initial treatment included amlodipine, bendroflumethiazide and losartan. Prior to discharge, a 24 hour urine collection showed a significantly elevated urinary noradrenaline level (3091 nmol/d, reference 0–473). Referral was made to the cardiovascular risk cli...

In population studies, premature cardiovascular disease is associated with cortisol dysregulation. Recently, recurrent hypoglycaemia in individuals with type 1 diabetes (T1D) was reported to be associated with increase carotid intima–media thickness. Hypoglycaemia is a potent activator of the hypothalamo-pituitary–adrenal axis (HPA axis) with eventual release of cortisol. We hypothesized that individuals with T1D who experience recurrent hypoglycaemia might demonstra...